T1-T2期声门癌患者接受或不接受化疗的放射治疗：回顾性分析
Radiotherapy with or without chemotherapy for patients with T1-T2 glottic carcinoma: retrospective analysis.
作者信息
Hirasawa Naoki, Itoh Yoshiyuki, Ishihara Shunichi, Kubota Seiji, Itoh Junji, Fujimoto Yasushi, Nakashima Tsutomu, Naganawa Shinji
机构信息
Department of Radiology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Shouwa-ku, Nagoya 4668550, Aichi, Japan.
Department of Otolaryngology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Shouwa-ku, Nagoya 4668550, Aichi, Japan.
出版信息
Head Neck Oncol. 2010 Jul 30;2:20. doi: 10.1186/1758-3284-2-20.
BACKGROUND
To assess the results for local control (LC) and survival in patients with early-stage glottic cancer (GC) who were treated by radiotherapy (RT) with or without chemotherapy.
METHODS
Fifty-eight patients with T1-T2 squamous cell carcinoma of the glottis who were treated between 2001 and 2006 were analyzed retrospectively. Potential prognostic factors for LC were evaluated by univariate analysis.
RESULTS
The 5-year LC rate in all patients was 84.3%. The overall 5-year LC rates for patients with T1a, Tb, and T2 GC were 85.9%, 83%, and 85%, respectively. Of the 58 patients, eight developed recurrent disease at the primary site, and one had lymph node recurrences on the neck. In the final analysis, the total laryngectomy-free survival rate was 93% at five years, and the ultimate LC rates for T1a, Tb, and T2 were 100%, 90.9%, and 95.2%, respectively. In a univariate analysis of 55 patients, there was no statistical significance between the LC rate for RT alone and that for chemoradiation. Only two patients died of laryngeal carcinoma, and one died of intercurrent disease. Fifty-five patients were living disease-free at the end of the study period. The 5-year overall survival (OS) rate for all patients was 88.1%, and the 5-year OS rates for T1a, Tb, and T2 were 91.6%, 77.8%, and 89.9%, respectively.
CONCLUSIONS
The retrospective analysis showed a high rate of LC and larynx preservation in patients with T1-T2 GC by means of RT with or without chemotherapy. There was, however, no statistical difference in LC rates for the two types of therapy.
背景
评估接受或未接受化疗的放射治疗（RT）的早期声门癌（GC）患者的局部控制（LC）和生存结果。
方法
回顾性分析2001年至2006年间接受治疗的58例声门T1-T2鳞状细胞癌患者。通过单因素分析评估LC的潜在预后因素。
结果
所有患者的5年LC率为84.3%。T1a、T1b和T2 GC患者的总体5年LC率分别为85.9%、83%和85%。58例患者中，8例在原发部位出现复发疾病，1例颈部出现淋巴结复发。最终分析显示，5年总喉切除术生存率为93%，T1a、T1b和T2的最终LC率分别为100%、90.9%和95.2%。在对55例患者的单因素分析中，单纯放疗与放化疗的LC率之间无统计学意义。仅2例死于喉癌，1例死于并发疾病。55例患者在研究期结束时无病生存。所有患者的5年总生存（OS）率为88.1%，T1a、T1b和T2的5年OS率分别为91.6%、77.8%和89.9%。
结论
回顾性分析显示，T1-T2 GC患者通过接受或未接受化疗的RT，LC率和喉保留率较高。然而，两种治疗方式的LC率无统计学差异。
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