T1a 和 T1b 声门型喉癌患者预后和治疗比较：基于倾向评分匹配 SEER 数据库分析。

Comparison of prognostic and treatment between T1a and T1b glottic cancer: a propensity score-matched SEER database analysis.

机构信息

Department of Otorhinolaryngology, Head and Neck Surgery, Zhongnan Hospital of Wuhan University, Wuhan, 430071, Hubei, China.

Sleep Medicine Centre, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.

出版信息

Eur Arch Otorhinolaryngol. 2023 Jul;280(7):3313-3322. doi: 10.1007/s00405-023-07953-7. Epub 2023 Apr 11.

DOI:10.1007/s00405-023-07953-7

PMID:37039896

Abstract

PURPOSE

The prognoses of T1a and T1b glottic cancers are still controversial. This study aimed to compare the prognosis difference between the two groups based on the population-based Surveillance, Epidemiology, and End Results database (SEER).

METHODS

Data for patients with T1a or T1b glottic cancers were extracted from the SEER database. The bias between T1a and T1b glottic cancers was minimized with Propensity Score Matching (PSM), and disease-specific survival (DSS) was analyzed using the Kaplan-Meier method, log-rank test, and Cox proportional hazards models.

RESULTS

A total of 5,272 patients were extracted from the database, including 847 patients with T1b glottic cancer that were 1:1 propensity score-matched with patients with T1a glottic cancer. After propensity score-matching, there was no statistical difference in disease-specific survival between T1a and T1b patients, whilst survival was impaired by old age. However, on the multivariate analysis, the T1a stage was associated with improved DSS compared with the T1b stage.

CONCLUSION

Our analysis showed that T1a glottic cancers didn't have a significantly better prognosis compared with T1b after PSM. However, the DSS of T1a patients is superior to that of T1b patients in multivariate analysis.

摘要

目的

T1a 和 T1b 声门型癌症的预后仍存在争议。本研究旨在基于基于人群的监测、流行病学和最终结果数据库（SEER）比较两组之间的预后差异。

方法

从 SEER 数据库中提取 T1a 或 T1b 声门型癌症患者的数据。采用倾向评分匹配（PSM）最小化 T1a 和 T1b 声门型癌症之间的偏差，并使用 Kaplan-Meier 方法、对数秩检验和 Cox 比例风险模型分析疾病特异性生存（DSS）。

结果

从数据库中提取了 5272 名患者，其中 847 名 T1b 声门型癌症患者与 T1a 声门型癌症患者进行了 1:1 的倾向评分匹配。在倾向评分匹配后，T1a 和 T1b 患者之间的疾病特异性生存无统计学差异，而年龄较大则会损害生存。然而，在多变量分析中，与 T1b 期相比，T1a 期与改善的 DSS 相关。