Ivanova M M, Sykulev Iu K, Blizniuk O I, Tumanova I A
Klin Med (Mosk). 1991 Mar;69(3):58-60.
Molecular weight and concentration characteristics of immune complexes (IC) from 19 sera of patients with systemic lupus erythematosus (SLE) and CNS impairment have been obtained by the rapid nephelometry assay. Basing on cranial CT findings, the examinees were divided into 2 groups. Group I included patients with cerebral cysts and local dilation of subarachonid spaces, group II those with the above dilatation or that of ventricles of the brain. Small-size IC were registered in 14 sera, their relative molecular mass being under the values derived for donors and SLE patients without CNS affections whereas their level exceeded such in donor sera. Larger IC relative concentrations were seen in group I patients than in group II ones (34 +/- 13 and 18.7 +/- 12, respectively). Five patients failed to demonstrate IC. The presence of small-size IC in high concentrations may be considered a marker of CNS involvement in SLE, the highest concentrations suggesting local impairment of the brain.
通过快速散射比浊法测定了19例患有系统性红斑狼疮（SLE）且有中枢神经系统损害的患者血清中免疫复合物（IC）的分子量和浓度特征。根据头颅CT检查结果，将受试者分为两组。第一组包括患有脑囊肿和蛛网膜下腔局部扩张的患者，第二组包括有上述扩张或脑室扩张的患者。在14份血清中检测到小尺寸IC，其相对分子质量低于供体及无中枢神经系统病变的SLE患者的值，但其水平高于供体血清中的水平。第一组患者中较大IC的相对浓度高于第二组患者（分别为34±13和18.7±12）。5例患者未检测到IC。高浓度小尺寸IC的存在可被视为SLE中枢神经系统受累的标志物，浓度最高表明脑部局部受损。
