University of Saskatchewan, Canada.
J Affect Disord. 2011 Jan;128(1-2):171-4. doi: 10.1016/j.jad.2010.06.040. Epub 2010 Jul 31.
Mood varies along at least 2 dimensions, severity and instability (MI). Compared with severity, there is little research on the treatment of MI. We assessed changes in MI with community psychiatric treatment, in patients with depression and mood swings.
Diagnoses were obtained with the MINI. Thirty-four patients completed the Mood Disorders Questionnaire, the Beck Depression Inventory (BDI) and the State-Trait Anxiety Inventory (STAI-T). MI was calculated from visual analogue scales (VAS) ratings for depression and anxiety. The VAS was rated twice a day for a week. The BDI, STAI-T and VAS were repeated after 3-6 months of treatment.
Patients improved with treatment on depression (BDI) and anxiety (STAI-T) severity but not on MI. However, change in MI predicted change in depression severity (BDI).
The sample size was relatively small and information on treatment was limited. There was no control group. Studies of longer duration and with more comprehensive treatment might be necessary to show changes in MI.
MI does not respond consistently within 3-6 months to common effective psychiatric treatments for depression and anxiety. Improved treatment of MI could result in improved treatment for major depression.
情绪至少沿两个维度变化，即严重程度和不稳定性（MI）。与严重程度相比，针对 MI 的治疗研究较少。我们评估了社区精神治疗对抑郁症和情绪波动患者 MI 的变化。
采用 MINI 进行诊断。34 名患者完成了心境障碍问卷、贝克抑郁量表（BDI）和状态特质焦虑量表（STAI-T）。MI 是根据抑郁和焦虑的视觉模拟量表（VAS）评分计算的。VAS 每周两次进行评分，为期一周。在治疗 3-6 个月后重复 BDI、STAI-T 和 VAS。
患者的抑郁（BDI）和焦虑（STAI-T）严重程度随治疗而改善，但 MI 未见改善。然而，MI 的变化预测了抑郁严重程度（BDI）的变化。
样本量相对较小，治疗信息有限。没有对照组。可能需要进行持续时间更长、治疗更全面的研究，以显示 MI 的变化。
在 3-6 个月内，常见有效的抗抑郁和抗焦虑精神治疗对 MI 反应不一致。改善 MI 的治疗可能会导致对重度抑郁症的治疗改善。
