具有类似抗体结合亲和力的合成受体。
Synthetic receptors with antibody-like binding affinities.
机构信息
Departments of Chemistry & Cancer Biology, The Scripps Research Institute, Scripps Florida, Jupiter, FL 33458, USA.
出版信息
Curr Opin Chem Biol. 2010 Dec;14(6):713-20. doi: 10.1016/j.cbpa.2010.07.001. Epub 2010 Jul 30.
Abstract
Antibodies are critical reagents in biological research and are increasingly being developed as therapeutic agents. They typically exhibit very high affinity and selectivity for their ligands. Synthetic protein-binding agents rarely achieve the combination of high affinity and selectivity for their target protein that is typical of a good antibody. However, significant efforts are underway to develop a new generation of protein ligands with improved properties. This article reviews progress towards this goal and suggests fruitful strategies for future research.
摘要
抗体是生物研究中的关键试剂，并且越来越多地被开发为治疗剂。它们通常对其配体表现出非常高的亲和力和选择性。合成的蛋白质结合剂很少能达到与目标蛋白质结合的高亲和力和选择性，而这是一个好的抗体的典型特征。然而，目前正在进行大量努力来开发具有改进性能的新一代蛋白质配体。本文综述了朝着这一目标取得的进展，并为未来的研究提出了富有成效的策略。
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