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肽、抗体、肽抗体及更多。

Peptides, Antibodies, Peptide Antibodies and More.

机构信息

Department of Neurology, Rigshospitalet Glostrup, Nordre Ringvej 57, 2600 Glostrup, Denmark.

Department of Drug Design and Pharmacology, Universitetsparken 2, 2100 Copenhagen Ø, Denmark.

出版信息

Int J Mol Sci. 2019 Dec 13;20(24):6289. doi: 10.3390/ijms20246289.

Abstract

The applications of peptides and antibodies to multiple targets have emerged as powerful tools in research, diagnostics, vaccine development, and therapeutics. Antibodies are unique since they, in theory, can be directed to any desired target, which illustrates their versatile nature and broad spectrum of use as illustrated by numerous applications of peptide antibodies. In recent years, due to the inherent limitations such as size and physical properties of antibodies, it has been attempted to generate new molecular compounds with equally high specificity and affinity, albeit with relatively low success. Based on this, peptides, antibodies, and peptide antibodies have established their importance and remain crucial reagents in molecular biology.

摘要

肽和抗体在多个靶点的应用已成为研究、诊断、疫苗开发和治疗的有力工具。抗体是独特的,因为理论上它们可以针对任何所需的目标,这说明了它们作为肽抗体的众多应用的多功能性和广泛用途。近年来,由于抗体的大小和物理性质等固有限制,人们试图生成具有同等高特异性和亲和力的新型分子化合物,但成功率相对较低。基于此,肽、抗体和肽抗体已经确立了它们的重要性,并仍然是分子生物学中的关键试剂。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a8b/6941022/adc5d9ba8fa3/ijms-20-06289-g001.jpg

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