Strelkova M V
Med Parazitol (Mosk). 1991 Jan-Feb(1):35-9.
40 R. opimus and 69 M. libycus were infected and 59 human subjects were vaccinated in laboratory conditions. 13 cultures of 3 leishmania species and their mixtures were used. R. opimus turned to be sensitive to 3 leishmania species. Leishmaniasis developed in the form of infiltrates irrespective of the leishmania species and pathogenic activity. Ulceration and visceralization were always absent. Differences in the duration of leishmania preservation in R. opimus have been noted. In L. major infection the mean disease duration was 7 months, in L. turanica infection it was 15 months, in L. gerbilli infection it was 18 months and in combined L. major and L. turanica infection the disease duration was 39 months. M. libycus proved to be sensitive to L. major and L. major/L. turanica mixture and resistant to L. turanica and L. gerbilli. In L. major infection ulceration (mean duration, 4 months) was observed. In combined L. major and L. turanica infection the signs varied from infiltrates to ulceration, with the disease duration increasing to 8.5 months. In human subjects, the typical course of leishmaniasis was observed only in L. major infection, when L. turanica with artificially increased pathogenic activity was administered, the course of skin lesions was abortive, which, however, in 1 volunteer led to the development of immunity to subsequent administration of L. major.
在实验室条件下，40只欧氏硬蜱和69只利比亚白蛉受到感染，59名人类受试者接种了疫苗。使用了3种利什曼原虫物种及其混合物的13种培养物。欧氏硬蜱对3种利什曼原虫物种敏感。无论利什曼原虫物种和致病活性如何，利什曼病均以浸润形式发展。溃疡和内脏化始终不存在。已注意到利什曼原虫在欧氏硬蜱体内保存时间的差异。在感染硕大利什曼原虫时，疾病平均持续时间为7个月；在感染图兰利什曼原虫时，为15个月；在感染沙鼠利什曼原虫时，为18个月；在硕大利什曼原虫和图兰利什曼原虫混合感染时，疾病持续时间为39个月。利比亚白蛉被证明对硕大利什曼原虫以及硕大利什曼原虫/图兰利什曼原虫混合物敏感，而对图兰利什曼原虫和沙鼠利什曼原虫有抗性。在感染硕大利什曼原虫时观察到溃疡（平均持续时间为4个月）。在硕大利什曼原虫和图兰利什曼原虫混合感染时，症状从浸润到溃疡不等，疾病持续时间增加到8.5个月。在人类受试者中，仅在感染硕大利什曼原虫时观察到典型的利什曼病病程，当接种致病性人工增强的图兰利什曼原虫时，皮肤病变病程为顿挫型，然而，在1名志愿者中，这导致了对随后接种硕大利什曼原虫产生免疫力。
