Department of Cardiology, Academic Medical Center, Amsterdam, The Netherlands.
Int J Cardiol. 2011 Oct 20;152(2):212-7. doi: 10.1016/j.ijcard.2010.07.018. Epub 2010 Aug 1.
Statistics on cause-specific mortality are important for prognostic research. The aim of this study was to assess the utility of the national mortality registry in research on causes of death in adult patients with congenital heart disease (CHD).
The CONCOR registry of over 10,000 adults with CHD was used to verify the causes of death provided by the WHO guidelines based national mortality registry, by linkage.
Of 7277 patients linked to the national mortality registry, 196 (2.4%) were recorded deceased, versus 228 deceased patients (3.1%) recorded in the CONCOR registry, during a follow-up of 25,900 patient years. Median age at death was 48.9 years. Of all deaths in the CONCOR registry, 77% had a cardiovascular origin; nearly 50% were due to progressive heart failure and arrhythmias. The national mortality registry recorded death due to progressive heart failure and arrhythmias in only 8.5%. Moreover, this registry recorded death with an 'unspecified' cause in approximately 30%, primarily containing patients who died due to progressive heart failure and arrhythmias according to their medical records.
WHO guidelines based national mortality registries lack the specificity and completeness needed for accurate research on causes of death in adult patients with CHD.
特定病因死亡率的统计数据对于预后研究很重要。本研究旨在评估国家死亡率登记处对于研究成人先天性心脏病（CHD）患者死因的实用性。
使用 CONCOR 登记处超过 10000 例成人 CHD 患者的数据，通过链接来验证世界卫生组织（WHO）指南所提供的死因与国家死亡率登记处的一致性。
在对 7277 例与国家死亡率登记处相关联的患者进行随访 25900 患者年后，有 196 例（2.4%）被记录为死亡，而 CONCOR 登记处记录了 228 例（3.1%）死亡患者。死亡时的中位年龄为 48.9 岁。在 CONCOR 登记处所有死亡中，77%有心血管起源；近 50%是由于进行性心力衰竭和心律失常。国家死亡率登记处仅记录了 8.5%的进行性心力衰竭和心律失常导致的死亡。此外，该登记处约 30%记录了“不明原因”的死亡，主要包含根据病历记录死于进行性心力衰竭和心律失常的患者。
基于 WHO 指南的国家死亡率登记处缺乏对成人 CHD 患者死因进行准确研究所需的特异性和完整性。
Zotero 插件