Gichner T, Baburek I, Velemínský J, Kappas A
Institute of Experimental Botany, Prague, Czechoslovakia.
Mutat Res. 1991 Jul;249(1):119-23. doi: 10.1016/0027-5107(91)90138-e.
UV-irradiation (254 nm, 10 or 20 J/cm2) of p-aminobenzoic acid (PABA) and p-aminosalicylic acid (NaPAS) potentiated their antimutagenicity towards N-methyl-N'-nitro-N-nitrosoguanidine mutagenesis in Salmonella typhimurium. Their inhibitory action towards the formation of the mutagen N-methyl-N-nitrosourea from the nitrosation mixture of N-methylurea and nitrite was also increased by UV-irradiation. In contrast, UV-irradiated PABA exhibited no inhibitory effects towards the mutagenicity of sodium azide or 3-azidoglycerol. Neither PABA nor NaPAS nor their UV-irradiation products were themselves mutagenic in the Ames assay.
对氨基苯甲酸（PABA）和对氨基水杨酸（NaPAS）经紫外线照射（254纳米，10或20焦耳/平方厘米）后，增强了它们对鼠伤寒沙门氏菌中N-甲基-N'-硝基-N-亚硝基胍诱变的抗诱变能力。紫外线照射也增强了它们对由N-甲基脲和亚硝酸盐的亚硝化混合物形成诱变剂N-甲基-N-亚硝基脲的抑制作用。相比之下，紫外线照射的PABA对叠氮化钠或3-叠氮甘油的诱变性没有抑制作用。在艾姆斯试验中，PABA、NaPAS及其紫外线照射产物本身都没有诱变性。
