大鼠神经分泌小体中催产素和加压素释放的调节：血管活性肠肽、催产素和γ-氨基丁酸的作用。

Modulation of oxytocin and vasopressin release from rat neurosecretosomes: the roles of VIP oxytocin and GABA.

作者信息

Falke N

机构信息

Sektion Elektronenmikroskopie, Universität Ulm, FRG.

出版信息

Neuropeptides. 1991 Mar;18(3):143-7. doi: 10.1016/0143-4179(91)90106-s.

DOI:10.1016/0143-4179(91)90106-s

PMID:2067599

Abstract

The effects of vasoactive intestinal polypeptide (VIP), of a selective oxytocin antagonist and of GABA on basal and stimulated oxytocin and vasopressin release from isolated neurosecretory endings were investigated. Superfusion of the secretosomes with VIP (10(-7) M) induced an increased basal and stimulated release of both oxytocin and vasopressin. Addition of the oxytocin antagonist induced a decrease of the stimulated oxytocin release as compared to the control which indicated a positive feedback mechanism of oxytocin on oxytocin release. In presence of GABA (1 or 50 microM) no change in basal or stimulated oxytocin and vasopressin release was observed.

摘要

研究了血管活性肠肽（VIP）、一种选择性催产素拮抗剂和γ-氨基丁酸（GABA）对从离体神经分泌末梢释放的基础及刺激状态下的催产素和加压素的影响。用VIP（10⁻⁷ M）对分泌小体进行灌流，可使基础及刺激状态下的催产素和加压素释放均增加。与对照组相比，加入催产素拮抗剂可使刺激状态下的催产素释放减少，这表明催产素对其自身释放存在正反馈机制。在存在GABA（1或50 μM）的情况下，未观察到基础或刺激状态下的催产素和加压素释放有变化。