Medical Ethics and History of Medicine Research Center, Tehran University of Medical Sciences, 3rd floor, 21# 16 Azar Ave, Tehran, Iran.
Rheumatol Int. 2011 Mar;31(3):289-300. doi: 10.1007/s00296-010-1586-z. Epub 2010 Jul 30.
Osteoporosis as a common chronic disease is challenging human health. Although different therapeutic options are routinely used for prevention/treatment of osteoporosis, their side effects and benefits are under question. Increasing our knowledge about signaling pathways in bone and osteocytes as well as osteoblasts and osteoclasts will help us in designing new therapeutic modalities for osteoporosis. In the present study, all new therapeutic measures of osteoporosis have been reviewed. For this purpose, search engines like Pubmed, Web of Science, Scopus, Google Scholar were searched and all relevant articles were found. The study was limited to the year 1998-2010. Bisphosphonates are the cornerstone of osteoporosis treatment, but there are not enough relevant studies that investigated their equivalencies in comparison with each other or the other medications. Therefore, medication selection is empirical and subjective. Furthermore, no eminent study has compared certain combinations. There are new hopes for treatment of osteoporosis, which are more specific with less harm. Our results show that new and emerging therapies are more potent and target specified which more individualize osteoporosis treatment; however, more investigations on their safety and efficacy in comparison with current medications are highly recommended.
骨质疏松症作为一种常见的慢性疾病，对人类健康构成挑战。虽然常规使用不同的治疗方法来预防/治疗骨质疏松症，但它们的副作用和益处仍存在争议。增加我们对骨和破骨细胞、成骨细胞中信号通路的了解，将有助于我们设计治疗骨质疏松症的新方法。在本研究中，我们综述了所有治疗骨质疏松症的新方法。为此，我们检索了 Pubmed、Web of Science、Scopus、Google Scholar 等搜索引擎，并找到了所有相关文章。研究仅限于 1998 年至 2010 年。双磷酸盐是骨质疏松症治疗的基石，但没有足够的相关研究来比较它们之间或与其他药物的等效性。因此，药物的选择是经验性和主观性的。此外，也没有杰出的研究比较某些组合。对于骨质疏松症的治疗有了新的希望，它们的针对性更强，危害更小。我们的研究结果表明，新出现的治疗方法更有效，针对性更强，使骨质疏松症的治疗更加个体化；然而，强烈建议对这些方法进行更多的安全性和有效性研究，与目前的药物进行比较。
