[支气管内超声引导下经支气管针吸活检术在肺癌诊断及分期中的初步经验]

[Initial experience on endobronchial ultrasound-guided transbronchial needle aspiration in the diagnosis and staging of lung cancer].

作者信息

Hu Hong, Chen Haiquan, Zhou Xian, Ping Bo, Feng Liqing, Zhou Jianhua, Luo Xiaoyang, Yang Fu, Ye Ting, Shen Lei

机构信息

Department of Thoracic Surgery, Cancer Hospital, Shanghai Medical College, Fudan University, Shanghai 200032, China.

出版信息

Zhongguo Fei Ai Za Zhi. 2010 May;13(5):438-42. doi: 10.3779/j.issn.1009-3419.2010.05.11.

DOI:10.3779/j.issn.1009-3419.2010.05.11

PMID:20677638

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6000704/

Abstract

BACKGROUND AND OBJECTIVE

It has been proven that endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) was a new minimally invasive method in the diagnosis for mediastinal lymph nodes. The aim of this study is to evaluate the diagnostic and staging yield of EBUS-TBNA for lung cancer.

METHODS

Seventy-five patients with tumors and enlarged mediastinal lymph nodes found by CT underwent the diagnosis by endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) from April 1, 2009 to Febuary 8, 2010. The sensitivity, specificity, positive predictive value, negative predictive value and diagnostic accuracy of EBUS-TBNA were evaluated.

RESULTS

Seventy-five patients with 177 lymph node groups (2.4 groups in average) were studied. Histopathological samples were found in 49.33% patients and in 28.81% groups. Overall sensitivity, specificity, positive predictive value, negative predictive value and diagnostic accuracy of EBUS-TBNA for diagnostic were 98.43%, 100.00%, 100.00%, 91.67% and 98.66%, respectively, in per patient analysis and were 95.10%, 100%, 100.00%, 82.93%, and 96.05%, respectively, in per group analysis, higher than CT examination (P < 0.05) expect for sensitivity (P = 0.435). Staging changed in 19 (26.03%) patients after EBUS-TBNA.

CONCLUSION

EBUS-TBNA proved to be a safe procedure with a high yield for the diagnosis of lung cancer.

摘要

背景与目的

已证实支气管内超声引导下经支气管针吸活检术（EBUS-TBNA）是诊断纵隔淋巴结的一种新型微创方法。本研究旨在评估EBUS-TBNA对肺癌的诊断及分期价值。

方法

2009年4月1日至2010年2月8日，对75例经CT发现有肿瘤且纵隔淋巴结肿大的患者进行支气管内超声引导下经支气管针吸活检术（EBUS-TBNA）诊断。评估EBUS-TBNA的敏感性、特异性、阳性预测值、阴性预测值及诊断准确性。

结果

研究了75例患者共177个淋巴结组（平均每组2.4个）。49.33%的患者及28.81%的淋巴结组获取了组织病理学样本。在 per patient分析中，EBUS-TBNA诊断的总体敏感性、特异性、阳性预测值、阴性预测值及诊断准确性分别为98.43%、100.00%、100.00%、91.67%和98.66%；在per group分析中分别为95.10%、100%、100.00%、82.93%和96.05%，除敏感性外均高于CT检查（P < 0.05，敏感性P = 0.435）。EBUS-TBNA后19例（26.03%）患者分期发生改变。