Hoskins I A, Friedman D M, Frieden F J, Ordorica S A, Young B K
Department of Obstetrics and Gynecology, New York University Medical Center, New York.
Obstet Gynecol. 1991 Aug;78(2):279-82.
We performed serial umbilical artery Doppler flow velocimetry studies on 314 women and grouped them according to history of antepartum cocaine abuse, placental abruption with antepartum cocaine abuse, preterm labor with antepartum cocaine abuse, preterm labor without antepartum cocaine abuse, and controls without preterm labor or antepartum cocaine abuse. Analyses excluded twin gestation, diabetes, and hypertension. The overall incidence of deliveries at or before 36 weeks was 28% (31 of 112). Thirteen (12%) of the infants were small for gestational age (SGA) and 33 (29%) were low birth weight (LBW). Almost all subjects with a history of cocaine abuse had normal systolic-diastolic ratios (S/Ds). All patients with abruption had abnormal S/Ds, as did 14 of 64 subjects who had preterm labor and a history of cocaine abuse. No abnormal S/Ds were found in the women with preterm labor or in controls. Among cocaine-abusing women, there was a significant correlation between placental abruption and abnormal S/Ds (P less than .05) and between abnormal S/Ds and the incidence of preterm birth and SGA and LBW infants.
我们对314名女性进行了系列脐动脉多普勒血流速度测定研究，并根据产前可卡因滥用史、伴有产前可卡因滥用的胎盘早剥、伴有产前可卡因滥用的早产、不伴有产前可卡因滥用的早产以及无早产或产前可卡因滥用的对照组对她们进行分组。分析排除了双胎妊娠、糖尿病和高血压。36周及以前分娩的总体发生率为28%（112例中的31例）。13名（12%）婴儿为小于胎龄儿（SGA），33名（29%）为低出生体重儿（LBW）。几乎所有有可卡因滥用史的受试者收缩-舒张比（S/Ds）均正常。所有胎盘早剥患者的S/Ds均异常，64名有早产和可卡因滥用史的受试者中有14名的S/Ds也异常。早产女性或对照组中未发现S/Ds异常。在滥用可卡因的女性中，胎盘早剥与异常S/Ds之间存在显著相关性（P小于0.05），异常S/Ds与早产、SGA和LBW婴儿的发生率之间也存在显著相关性。
