Dhankhar Ritu, Vyas Suresh P, Jain Arvind K, Arora Sahil, Rath Goutam, Goyal Amit K
Nanomedicine Research Centre, Department of Pharmaceutics, Indo-Soviet Friendship College of Pharmacy, GT Road, Moga, Punjab, India.
Artif Cells Blood Substit Immobil Biotechnol. 2010 Oct;38(5):230-49. doi: 10.3109/10731199.2010.494578.
Breast cancer remains one of the world's most devastating diseases. However, better understanding of tumor biology and improved diagnostic devices could lead to improved therapeutic outcomes. Nanotechnology has the potential to revolutionize cancer diagnosis and therapy. Various nanocarriers have been introduced to improve the therapeutic efficacy of anticancer drugs, including liposomes, polymeric micelles, quantum dots, nanoparticles, and dendrimers. Recently, targeted drug delivery systems for anti-tumor drugs have demonstrated great potential to lower cytotoxicity and increase therapeutic effects. Various ligands/approaches have been explored for targeting breast cancer. This paper provides an overview of breast cancer, conventional therapy, potential of nanotechnology in management of breast cancer, and rational approaches for targeting breast cancer.
乳腺癌仍然是全球最具毁灭性的疾病之一。然而，对肿瘤生物学的更深入了解以及诊断设备的改进可能会带来更好的治疗效果。纳米技术有潜力彻底改变癌症的诊断和治疗方式。已经引入了各种纳米载体来提高抗癌药物的治疗效果，包括脂质体、聚合物胶束、量子点、纳米颗粒和树枝状大分子。最近，抗肿瘤药物的靶向给药系统已显示出降低细胞毒性和提高治疗效果的巨大潜力。人们已经探索了各种配体/方法来靶向乳腺癌。本文概述了乳腺癌、传统疗法、纳米技术在乳腺癌治疗中的潜力以及靶向乳腺癌的合理方法。
