Pial Mohammad Mohtasim Hamid, Tomitaka Asahi, Pala Nezih, Roy Upal
Department of Electrical and Computer Engineering, Florida International University, Miami, FL 33174, USA.
Department of Immunology and Nano-Medicine, Herbert Wertheim College of Medicine, Florida International University, Miami, FL 33199, USA.
J Nanotheranostics. 2022 Mar;3(1):19-38. doi: 10.3390/jnt3010003. Epub 2022 Feb 9.
Breast cancer is one of the leading causes of death in the female population worldwide. Standard treatments such as chemotherapy show noticeable results. However, along with killing cancer cells, it causes systemic toxicity and apoptosis of the nearby healthy cells, therefore patients must endure side effects during the treatment process. Implantable drug delivery devices that enhance therapeutic efficacy by allowing localized therapy with programmed or controlled drug release can overcome the shortcomings of conventional treatments. An implantable device can be composed of biopolymer materials, nanocomposite materials, or a combination of both. This review summarizes the recent research and current state-of-the art in these types of implantable devices and gives perspective for future directions.
乳腺癌是全球女性群体中主要的死亡原因之一。化疗等标准治疗方法显示出显著效果。然而，在杀死癌细胞的同时，它会导致全身毒性以及附近健康细胞的凋亡，因此患者在治疗过程中必须忍受副作用。通过实现程序化或可控药物释放的局部治疗来提高治疗效果的可植入药物递送装置，可以克服传统治疗方法的缺点。可植入装置可以由生物聚合物材料、纳米复合材料或两者的组合构成。本综述总结了这类可植入装置的最新研究和当前技术水平，并给出了未来方向的展望。
