氟化物缓释系统的研制。
Development of a sustained fluoride delivery system.
机构信息
Naval Research Laboratories, Alexandria, VA, USA.
出版信息
Angle Orthod. 2010 Nov;80(6):1129-35. doi: 10.2319/112309-664.1.
OBJECTIVE
To develop a novel delivery system by which fluoride incorporated into elastomeric rings, such as those used to ligate orthodontic wires, will be released in a controlled and constant manner.
MATERIALS AND METHODS
Polyethylene co-vinyl acetate (PEVA) was used as the model elastomer. Samples (N = 3) were prepared by incorporating 0.02 to 0.4 g of sodium fluoride (NaF) into previously prepared PEVA solution. Another group of samples prepared in the same manner were additionally dip-coated in PEVA to create an overcoat. Fluoride release studies were conducted in vitro using an ion selective electrode over a period of 45 days. The amount of fluoride released was compared to the optimal therapeutic dose of 0.7 microg F(-)/ring/d.
RESULTS
Only coated samples with the highest fluoride content (group D, 0.4 g of NaF) were able to release fluoride at therapeutic levels. When fluoride release from coated and uncoated samples with the same amount of NaF were compared, it was shown that the dip-coating technique resulted in a fluoride release in a controlled manner while eliminating the initial burst effect.
CONCLUSIONS
This novel fluoride delivery matrix provided fluoride release at a therapeutically effective rate and profile.
目的
开发一种新型给药系统，使结合到弹性环（如用于结扎正畸丝的弹性环）中的氟以受控和恒定的方式释放。
材料和方法
聚乙烯共醋酸乙烯酯（PEVA）用作模型弹性体。通过将 0.02 至 0.4 克氟化钠（NaF）掺入先前制备的 PEVA 溶液中制备样品（N = 3）。以相同的方式制备的另一组样品另外进行了 PEVA 浸涂以形成包被。通过离子选择性电极在 45 天的时间内进行体外氟释放研究。释放的氟化物量与最佳治疗剂量 0.7μg F(-)/环/d 进行比较。
结果
仅含有最高氟化物含量的涂层样品（组 D，0.4 g NaF）能够以治疗水平释放氟化物。当比较具有相同 NaF 含量的涂层和未涂层样品的氟释放时，表明浸涂技术以受控的方式释放氟化物，同时消除了初始突释效应。
结论
这种新型氟化物给药基质提供了治疗有效率和特征的氟化物释放。
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