Syed Muhammad Ali, Pervaiz Saima
Department of Biosciences, Comsats Institute of Information Technology, Islamabad, Pakistan.
Oligonucleotides. 2010 Oct;20(5):215-24. doi: 10.1089/oli.2010.0234. Epub 2010 Aug 2.
Aptamers are nucleic acid sequences synthesized through in vitro selection and amplification technique, possessing a broader range of applications in therapeutics, biosensing, diagnostics, and research. Aptamers offer a number of advantages over their antibodies counterpart, one of them is their ability to undergo chemical derivatization to increase their life in the body fluids and bioavailability in animals. Although aptamers were discovered in 1990s, they have become one of the most widely investigated molecules, with a huge number of publications in the last decade. This article presents an overview of the advancements that have been made in aptamers. We mainly focused on articles published since 2005.
适体是通过体外筛选和扩增技术合成的核酸序列，在治疗、生物传感、诊断和研究等领域具有更广泛的应用。与抗体相比，适体具有许多优势，其中之一是它们能够进行化学衍生化，以延长其在体液中的寿命并提高在动物体内的生物利用度。尽管适体在20世纪90年代就已被发现，但它们已成为研究最广泛的分子之一，在过去十年中有大量相关出版物。本文概述了适体领域所取得的进展。我们主要关注2005年以来发表的文章。
