Department of Internal Medicine, Henry Ford Hospital, CFP 559, 2799 West Grand Blvd, Detroit, MI 48202, USA.
J Hematol Oncol. 2010 Aug 2;3:26. doi: 10.1186/1756-8722-3-26.
Prostate cancer remains a significant public health problem, with limited therapeutic options in the setting of castrate-resistant metastatic disease. Angiogenesis inhibition is a relatively novel antineoplastic approach, which targets the reliance of tumor growth on the formation of new blood vessels. This strategy has been used successfully in other solid tumor types, with the FDA approval of anti-angiogenic agents in breast, lung, colon, brain, and kidney cancer. The application of anti-angiogenic therapy to prostate cancer is reviewed in this article, with attention to efficacy and toxicity results from several classes of anti-angiogenic agents. Ultimately, the fate of anti-angiogenic agents in prostate cancer rests on the eagerly anticipated results of several key phase III studies.
前列腺癌仍然是一个重大的公共卫生问题,在去势抵抗性转移性疾病的情况下,治疗选择有限。血管生成抑制是一种相对较新的抗肿瘤方法,针对肿瘤生长对新血管形成的依赖。这一策略已在其他实体肿瘤类型中成功应用,美国食品和药物管理局 (FDA) 已批准抗血管生成药物用于乳腺癌、肺癌、结肠癌、脑癌和肾癌。本文综述了抗血管生成治疗在前列腺癌中的应用,重点关注了几类抗血管生成药物的疗效和毒性结果。最终,抗血管生成药物在前列腺癌中的命运取决于几项关键 III 期研究的预期结果。