Yang Zhengyang, Deng Wei, Zhang Xiao, An Yongbo, Liu Yishan, Yao Hongwei, Zhang Zhongtao
Department of General Surgery, Beijing Friendship Hospital, Capital Medical University and National Clinical Research Center for Digestive Diseases, Beijing, China.
Front Oncol. 2022 Jan 10;11:789330. doi: 10.3389/fonc.2021.789330. eCollection 2021.
Digestive tumours, a common kind of malignancy worldwide, have recently led to the most tumour-related deaths. Angiogenesis, the process of forming novel blood vessels from pre-existing vessels, is involved in various physiological and pathological processes in the body. Many studies suggest that abnormal angiogenesis plays an important role in the growth, progression, and metastasis of digestive tumours. Therefore, anti-angiogenic therapy is considered a promising target for improving therapeutic efficacy. Traditional strategies such as bevacizumab and regorafenib can target and block the activity of proangiogenic factors to treat digestive tumours. However, due to resistance and some limitations, such as poor pharmacokinetics, their efficacy is not always satisfactory. In recent years, nanotechnology-based anti-angiogenic therapies have emerged as a new way to treat digestive tumours. Compared with commonly used drugs, nanoparticles show great potential in tumour targeted delivery, controlled drug release, prolonged cycle time, and increased drug bioavailability. Therefore, anti-angiogenic nanoparticles may be an effective complementary therapy to treat digestive tumours. In this review, we outline the different mechanisms of angiogenesis, the effects of nanoparticles on angiogenesis, and their biomedical applications in various kinds of digestive tumours. In addition, the opportunities and challenges are briefly discussed.
消化肿瘤是全球常见的一种恶性肿瘤，最近已导致最多的肿瘤相关死亡。血管生成是指从已有的血管形成新血管的过程，参与身体的各种生理和病理过程。许多研究表明，异常血管生成在消化肿瘤的生长、进展和转移中起重要作用。因此，抗血管生成治疗被认为是提高治疗效果的一个有前景的靶点。传统策略如贝伐单抗和瑞戈非尼可以靶向并阻断促血管生成因子的活性来治疗消化肿瘤。然而，由于耐药性和一些局限性，如药代动力学不佳，它们的疗效并不总是令人满意。近年来，基于纳米技术的抗血管生成治疗已成为治疗消化肿瘤的一种新方法。与常用药物相比，纳米颗粒在肿瘤靶向递送、药物控释、延长循环时间和提高药物生物利用度方面显示出巨大潜力。因此，抗血管生成纳米颗粒可能是治疗消化肿瘤的一种有效的辅助治疗方法。在这篇综述中，我们概述了血管生成的不同机制、纳米颗粒对血管生成的影响及其在各种消化肿瘤中的生物医学应用。此外，还简要讨论了机遇和挑战。
