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成年斑马鱼作为行为遗传学的模式生物。

Adult zebrafish as a model organism for behavioural genetics.

机构信息

CNRS, UPR, Institute of Neurobiology Albert Fessard, Gif-sur-Yvette, France.

出版信息

BMC Neurosci. 2010 Aug 2;11:90. doi: 10.1186/1471-2202-11-90.

Abstract

Recent research has demonstrated the suitability of adult zebrafish to model some aspects of complex behaviour. Studies of reward behaviour, learning and memory, aggression, anxiety and sleep strongly suggest that conserved regulatory processes underlie behaviour in zebrafish and mammals. The isolation and molecular analysis of zebrafish behavioural mutants is now starting, allowing the identification of novel behavioural control genes. As a result of this, studies of adult zebrafish are now helping to uncover the genetic pathways and neural circuits that control vertebrate behaviour.

摘要

最近的研究表明,成年斑马鱼适合模拟复杂行为的某些方面。关于奖励行为、学习和记忆、攻击行为、焦虑和睡眠的研究强烈表明,调控过程在斑马鱼和哺乳动物的行为中是保守的。斑马鱼行为突变体的分离和分子分析现在已经开始,这使得鉴定新的行为控制基因成为可能。因此,对成年斑马鱼的研究现在正在帮助揭示控制脊椎动物行为的遗传途径和神经回路。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f2c2/2919542/cf9993638ddd/1471-2202-11-90-1.jpg

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