Autism Research Centre, Department of Psychiatry, University of Cambridge, Douglas House, 18b Trumpington Rd, Cambridge, CB2 8AH, UK.
Mol Autism. 2010 Jun 17;1(1):10. doi: 10.1186/2040-2392-1-10.
The Autism Spectrum Quotient (AQ) is a self-report questionnaire for quantifying autistic traits. This study tests whether the AQ can differentiate between parents of children with an autism spectrum condition (ASC) and control parents. In this paper, the use of the AQ to define the broader, medium and narrow autism phenotypes (BAP, MAP, NAP) is reported, and the proportion of parents with each phenotype is compared between the two groups.
A sample of 571 fathers and 1429 mothers of children with an ASC completed the AQ, along with 349 fathers and 658 mothers of developing typically children.
Both mothers and fathers of the diagnosed children scored higher than the control parents on total AQ score and on four out of five of the subscales. Additionally, there were more parents of diagnosed children with a BAP, MAP or NAP.
The AQ provides an efficient method for quantifying where an individual lies along the dimension of autistic traits, and extends the notion of a broader phenotype among first-degree relatives of those with ASC. The AQ is likely to have many applications, including population and clinical screening, and stratification in genetic studies.
自闭症谱系商数（AQ）是一种自我报告问卷，用于量化自闭症特征。本研究测试 AQ 是否可以区分自闭症谱系障碍（ASC）儿童的父母和对照组父母。本文报告了使用 AQ 定义更广泛、中等和狭义自闭症表型（BAP、MAP、NAP）的情况，并比较了两组中每种表型的父母比例。
571 名 ASC 儿童的父亲和 1429 名母亲以及 349 名发育正常儿童的父亲和 658 名母亲完成了 AQ 测试。
诊断为 ASC 的儿童的母亲和父亲在 AQ 总分以及五个分量表中的四个分量表上的得分均高于对照组父母。此外，诊断为 ASC 的儿童的父母中，具有 BAP、MAP 或 NAP 的比例更高。
AQ 提供了一种量化个体在自闭症特征维度上所处位置的有效方法，并扩展了 ASC 患者一级亲属中更广泛表型的概念。AQ 可能有许多应用，包括人群和临床筛查以及遗传研究中的分层。
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