Faculty of Veterinary Science, University of Sydney, NSW 2006, Australia.
Res Vet Sci. 2011 Jun;90(3):510-5. doi: 10.1016/j.rvsc.2010.07.003. Epub 2010 Aug 1.
Inflammatory airway disease (IAD) is common in racehorses, and is a cause of wastage in the industry. IAD has been diagnosed by measurement of percent neutrophils (N%) in tracheal aspirates (TA). The aim of this study was to investigate whether spirometric indices of pulmonary function were correlated with N% in TAs. Limits to breathing were measured by analyses of relationships between relative times and relative respiratory gas flows during inspiration and expiration in individual breaths recorded after exercise. Horses with higher N% had significantly lower relative gas flows at the same relative times during inspiration and expiration, suggesting a limit to breathing. These findings confirm a physiological basis for the measurement of N% in TA after exercise for diagnosis of IAD. Spirometric pulmonary function testing using analyses of individual breaths after exercise has application for assessment of pulmonary function and poor exercise performance.
炎性气道疾病（IAD）在赛马中很常见，是该行业损耗的一个原因。IAD 通过测量气管抽吸物（TA）中的中性粒细胞百分比（N%）来诊断。本研究的目的是调查肺功能的肺活量指数是否与 TA 中的 N%相关。通过分析个体呼吸记录的吸气和呼气过程中相对时间和相对呼吸气流之间的关系来测量呼吸受限。N%较高的马匹在吸气和呼气过程中的相同相对时间内的相对气流明显较低，表明存在呼吸受限。这些发现证实了运动后 TA 中 N%测量用于诊断 IAD 的生理学基础。使用运动后个体呼吸分析的肺活量肺功能测试可用于评估肺功能和运动表现不佳。
