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英国多塞特郡皮肤头颈黑色素瘤的回顾性研究。

Retrospective study on the cutaneous head and neck melanoma in Dorset (UK).

作者信息

Komisarovas Larissa, Jayasinghe Chandima, Seah Tian Ee, Ilankovan Velupillai

机构信息

Poole Hospital NHS Foundation Trust, Department of Oral and Maxillofacial Surgery, Longfleet Road, Poole BH15 2JB, UK.

出版信息

Br J Oral Maxillofac Surg. 2011 Jul;49(5):359-63. doi: 10.1016/j.bjoms.2010.06.016. Epub 2010 Aug 3.

Abstract

Trends in the incidence and the sites of primary malignant melanoma on the skin of head and neck in Dorset as well as the outcome of treated cases were overviewed for the first time. Increase in incidence rate of cutaneous head and neck melanoma from 1.3 per 100,000 in 2004 to 3.1 per 100,000 in 2007 was recorded. The most prevalent histogenetic type of cutaneous malignant melanoma on head and neck in our study was melanoma of superficial spreading type 35.1% (n=20) of all registered cases. Superficial spreading melanoma apart from being the most common type of malignant melanoma of the head and neck in Dorset also showed increase in the number of diagnosed cases of the reviewed years. It increased from 2 (22.2%) of all head and neck melanoma cases in 2004 to 7 (30.4%) in 2007. The average age at the time of diagnosis the cutaneous malignant melanoma of head and neck for both men and women was 73.5 years. Breslow thickness, Clark's level of invasion, tumour ulceration and anatomical site remained the most important prognostic factors. Correlation between Breslow thickness and Clark's level of invasion found to be stronger in men.

摘要

首次概述了多塞特郡头颈部皮肤原发性恶性黑色素瘤的发病率、发病部位趋势以及治疗病例的结果。记录显示,头颈部皮肤黑色素瘤的发病率从2004年的每10万人1.3例增至2007年的每10万人3.1例。在我们的研究中,头颈部皮肤恶性黑色素瘤最常见的组织发生类型是浅表扩散型黑色素瘤,占所有登记病例的35.1%(n = 20)。浅表扩散型黑色素瘤不仅是多塞特郡头颈部最常见的恶性黑色素瘤类型,在回顾的年份中诊断病例数也有所增加。它从2004年占所有头颈部黑色素瘤病例的2例(22.2%)增至2007年的7例(30.4%)。男性和女性头颈部皮肤恶性黑色素瘤的平均诊断年龄为73.5岁。Breslow厚度、Clark浸润水平、肿瘤溃疡和解剖部位仍然是最重要的预后因素。发现Breslow厚度与Clark浸润水平之间的相关性在男性中更强。

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