Milo Y, Tamir G, Robinpour M, Sulkes J, Rotem A, Schachter J, Hauben D J
Dept. of Plastic Surgery, Beilinson Medical Center, Petah Tikva.
Harefuah. 1995 Jun 15;128(12):745-51, 824.
207 patients with primary cutaneous malignant melanoma were admitted between August 1, 1988 and July 31, 1992 for local excision and treatment. The female to male ratio was 1.4:1 and the peak age was in the seventies. The most frequent site in males was the back and in females the legs. Superficial spreading melanoma was the most frequent type (40%); there was also a high rate of nodular melanoma (20%), particularly in males. Thin melanomas accounted for most of the cases. On follow-up 27 (13%) developed metastases in transit or in regional lymph nodes and 10 (5%) developed distant metastases; 2 (1%) had locally recurrent melanoma and 2 died of metastatic melanoma. There was a significant positive correlation between Breslow thickness, Clark's level of invasion, histopathological ulceration, nodular and acral lentiginous type of lesion and development of metastases. These data may be valuable for public and professional education and in the prediction of outcome of melanoma.
1988年8月1日至1992年7月31日期间，收治了207例原发性皮肤恶性黑色素瘤患者进行局部切除和治疗。男女比例为1.4:1，发病高峰年龄在七十岁。男性最常见的发病部位是背部，女性是腿部。浅表扩散型黑色素瘤是最常见的类型（40%）；结节型黑色素瘤的发生率也较高（20%），尤其在男性中。薄黑色素瘤占大多数病例。随访中，27例（13%）出现了移行转移或区域淋巴结转移，10例（5%）出现了远处转移；2例（1%）发生了局部复发性黑色素瘤，2例死于转移性黑色素瘤。Breslow厚度、Clark浸润水平、组织病理学溃疡、结节型和肢端雀斑样痣型病变与转移的发生之间存在显著正相关。这些数据对于公众和专业教育以及黑色素瘤预后的预测可能具有重要价值。
