斯里兰卡疲劳症的病因及其与抑郁症的重叠。
Aetiology of fatigue in Sri Lanka and its overlap with depression.
机构信息
MRC Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King's College London, De Crespigny Park, London SE5 8AF.
出版信息
Br J Psychiatry. 2010 Aug;197(2):106-13. doi: 10.1192/bjp.bp.109.069674.
BACKGROUND
Fatigue is a common symptom in Western high-income countries but is often medically unexplained and little is known about its presentation in other populations.
AIMS
To explore the epidemiology and aetiology of fatigue in Sri Lanka, and of its overlap with depression.
METHOD
A total of 4024 randomly selected twins from a population-based register in Sri Lanka (Colombo district) completed home interviews including the Chalder Fatigue Questionnaire.
RESULTS
The prevalence of fatigue was similar to that in other countries, although prolonged fatigue may be less common. There was substantial comorbidity with a screen for lifetime depression. Non-shared environmental factors made the largest contributions, although genetic/family factors also contributed. The aetiology appeared consistent across the spectrum of severity.
CONCLUSIONS
The aetiology of fatigue is broadly similar in Sri Lanka and Western high-income countries. Abnormal experiences of fatigue appear to be the extreme form of more common fatigue, rather than representing independent entities with different genetic or environmental risk factors.
背景
疲劳是西方国家高收入人群中常见的症状，但往往无法从医学上解释，而对于其他人群中疲劳的表现知之甚少。
目的
探讨斯里兰卡疲劳的流行病学和病因学，以及其与抑郁的重叠。
方法
从斯里兰卡（科伦坡区）的一项基于人群的登记处随机抽取了 4024 对双胞胎，他们在家中接受了包括 Chalder 疲劳问卷在内的访谈。
结果
疲劳的患病率与其他国家相似，尽管持续性疲劳可能不太常见。与终身抑郁的筛查存在很大的共病。非共享环境因素的贡献最大，尽管遗传/家庭因素也有贡献。病因在严重程度的整个范围内似乎是一致的。
结论
疲劳的病因在斯里兰卡和西方国家大致相似。异常的疲劳体验似乎是更常见的疲劳的极端形式，而不是代表具有不同遗传或环境风险因素的独立实体。
Zotero 插件