遗传因素和环境因素对斯里兰卡抑郁症的影响。
Genetic and environmental contributions to depression in Sri Lanka.
作者信息
Ball Harriet A, Sumathipala Athula, Siribaddana Sisira H, Kovas Yulia, Glozier Nick, McGuffin Peter, Hotopf Matthew
机构信息
MRC Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King's College London, De Crespigny Park, London SE5 8AF, UK.
出版信息
Br J Psychiatry. 2009 Dec;195(6):504-9. doi: 10.1192/bjp.bp.109.063529.
Abstract
BACKGROUND
Susceptibility to depression results from genetic and non-familially shared environmental influences in high-income, Western countries. Environments may play a different role for populations in different contexts.
AIMS
To examine heritability of depression in the first large, population-based twin study in a low-income country.
METHOD
Lifetime depression and a broader measure of depression susceptibility (D-probe) were assessed in 3908 adult twins in Sri Lanka (the CoTASS study).
RESULTS
There were gender differences for the broad definition (D-probe), with a higher genetic contribution in females (61%) than males (4%). Results were similar for depression, but the prevalence was too low to estimate heritability for males.
CONCLUSIONS
Genetic influences on depression in women appear to be at least as strong in this Sri Lankan sample as in higher-income countries. Conclusions are less clear for men but suggest a larger role for environments rather than genes. The nature as well as the magnitude of environmental influences may also differ across populations.
摘要
背景
在高收入的西方国家，抑郁症易感性源于遗传和非家族共享的环境影响。环境在不同背景下对人群可能发挥不同作用。
目的
在低收入国家进行的首次大规模基于人群的双胞胎研究中，考察抑郁症的遗传度。
方法
在斯里兰卡对3908名成年双胞胎进行了终生抑郁和更广泛的抑郁易感性测量（D探针）（CoTASS研究）。
结果
对于宽泛定义（D探针）存在性别差异，女性的遗传贡献（61%）高于男性（4%）。抑郁症的结果相似，但患病率过低，无法估计男性的遗传度。
结论
在这个斯里兰卡样本中，遗传因素对女性抑郁症的影响似乎至少与高收入国家一样强烈。男性的结论不太明确，但表明环境而非基因发挥了更大作用。环境影响的性质和程度在不同人群中也可能不同。
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