Matias-Guiu X, Esquius J
Department of Pathology, Hospital de la Santa Creu i Sant Pau, Autonomous University of Barcelona, Spain.
Pathol Res Pract. 1991 Mar;187(2-3):296-300. doi: 10.1016/S0344-0338(11)80787-9.
In order to assess the specificity of lymphoepithelial lesion (LEL) in the diagnosis of thyroid lymphoma, the thyroid glands of patients with Hashimoto's disease, lymphoid infiltrates in the vicinity of papillary carcinoma, focal thyroiditis in Graves' disease and malignant lymphoma of the thyroid were studied by conventional pathological and immunohistochemical techniques using a panel of antibodies against epithelial cells (CAM 5.2) and leucocytes (LCA, pan-T, and pan-B antisera). LEL was encountered in all cases. In cases of peritumoral lymphoid infiltrates LEL represented a focal phenomenon, whereas in Hashimoto's and Graves' diseases and lymphoma, it was found in multiple areas. In cases of malignant lymphoma LEL was encountered in the vicinity of areas where diffuse parenchymal destruction by tumor cells had occurred. The results suggested that although LEL is almost always present in lymphomas it can also be encountered in other diseases of the thyroid. If therefore LEL has no diagnostic specificity, the diagnosis of malignant lymphoma must be supported by other histological findings.
为了评估淋巴上皮病变（LEL）在甲状腺淋巴瘤诊断中的特异性，我们采用一组抗上皮细胞（CAM 5.2）和白细胞（LCA、泛T和泛B抗血清）的抗体，通过传统病理和免疫组化技术，对桥本氏病患者的甲状腺、乳头状癌周围的淋巴浸润、格雷夫斯病中的局灶性甲状腺炎以及甲状腺恶性淋巴瘤进行了研究。所有病例均发现有LEL。在肿瘤周围淋巴浸润的病例中，LEL表现为局灶性现象，而在桥本氏病、格雷夫斯病和淋巴瘤中，则在多个区域发现。在恶性淋巴瘤病例中，在肿瘤细胞弥漫性实质破坏的区域附近发现了LEL。结果表明，虽然LEL几乎总是存在于淋巴瘤中，但在甲状腺的其他疾病中也可能出现。因此，如果LEL没有诊断特异性，恶性淋巴瘤的诊断必须得到其他组织学发现的支持。
