Department of Obstetrics and Gynaecology, Post Graduate Institute of Medical Education and Research, Chandigarh 160 012, India.
Arch Gynecol Obstet. 2011 Aug;284(2):281-5. doi: 10.1007/s00404-010-1618-7. Epub 2010 Aug 1.
To evaluate pregnancy outcome in women with systemic lupus erythematosus (SLE).
A total of 71 pregnancies in 35 women with SLE were evaluated for maternal and perinatal outcomes in a tertiary centre of Northern India. Thirty-five pregnancies were evaluated prospectively while details of previous 36 pregnancies in the same women were studied retrospectively.
The Mean age of pregnant women with SLE was 26.89 ± 2.7 years and 14.57% were nulliparous. The presenting event was arthritis in 60% of the patients; others presented with febrile illness, renal manifestation and cutaneous manifestation. One woman was lupus anticoagulant positive. All women conceived while on disease quiescence period and were continued on the same pre-pregnancy dose of pharmacological agents. Hypertensive disorders of pregnancy were seen in 28.5% while chronic hypertension was seen in 5.6%. The incidence of abortion, preterm deliveries and perinatal loss was 33.8, 29.57 and 12.67%, respectively. Vaginal delivery rate was 47.88 and 18.3% underwent caesarean section. There was no case of neonatal lupus and none had disease flare-up in the postpartum period.
A better pregnancy outcome can be expected if clinical remission is achieved and disease activity is adequately controlled prior to pregnancy.
评估系统性红斑狼疮（SLE）女性的妊娠结局。
在印度北部的一家三级中心，对 35 名患有 SLE 的女性的 71 次妊娠进行了评估，以了解母婴和围产期结局。35 次妊娠进行了前瞻性评估，而对同一女性的前 36 次妊娠的详细信息进行了回顾性研究。
SLE 孕妇的平均年龄为 26.89 ± 2.7 岁，14.57%为初产妇。60%的患者首发症状为关节炎；其他表现为发热性疾病、肾脏表现和皮肤表现。1 名女性狼疮抗凝剂阳性。所有女性均在疾病静止期怀孕，并继续使用相同的孕前药物剂量。28.5%出现妊娠高血压疾病，5.6%出现慢性高血压。流产、早产和围产儿死亡的发生率分别为 33.8%、29.57%和 12.67%。阴道分娩率为 47.88%，18.3%行剖宫产术。无新生儿狼疮病例，也无产后疾病活动。
如果在怀孕前实现临床缓解并充分控制疾病活动，可预期更好的妊娠结局。
