Wistar-Kyoto 和 Wistar 大鼠饮酒模式和多巴胺-2 受体结合的差异。
Differential patterns of alcohol consumption and dopamine-2 receptor binding in Wistar-Kyoto and Wistar rats.
机构信息
Department of Pharmaceutical Sciences, University of the Sciences in Philadelphia, Philadelphia, PA 19104, USA.
出版信息
Neurochem Res. 2010 Nov;35(11):1708-15. doi: 10.1007/s11064-010-0233-0. Epub 2010 Aug 3.
The Wistar-Kyoto (WKY) rat strain has been described as an animal model of depressive behavior that consumes significantly greater amounts of alcohol compared to the Wistar (WIS) rat strain. Since the mesolimbic dopamine (DA) type-2 (D2) receptors mediate reward-related behaviors, the present study measured the binding of [(125)I]-Iodosulpiride to D2 receptors in the brains of WKY versus WIS rats following 24 days of voluntary alcohol or water consumption. Alcohol consuming WKY rats showed a significant increase in D2 receptor binding in several regions of the mesolimbic and nigrostriatal systems. In contrast, alcohol consuming WIS rats showed a reduction in D2 receptor binding in DA cell body areas. The differential regulation of D2 receptors by voluntary alcohol consumption in the two rat strains suggests that D2 receptor mediated neurotransmission may be playing a role in the increased alcohol drinking behavior reported in WKY rats.
Wistar-Kyoto（WKY）大鼠品系已被描述为一种抑郁行为的动物模型，与 Wistar（WIS）大鼠相比，其酒精摄入量明显更多。由于中脑边缘多巴胺（DA）类型 2（D2）受体介导与奖励相关的行为，本研究测量了在自愿饮酒或饮水 24 天后，WKY 与 WIS 大鼠大脑中[(125)I]-碘代舒必利与 D2 受体的结合。饮酒的 WKY 大鼠在中脑边缘和黑质纹状体系统的几个区域显示 D2 受体结合显著增加。相比之下，饮酒的 WIS 大鼠在 DA 细胞体区域显示 D2 受体结合减少。两种大鼠品系中自愿饮酒对 D2 受体的不同调节表明，D2 受体介导的神经传递可能在 WKY 大鼠报告的饮酒行为增加中发挥作用。
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