University of California, Los Angeles, Henry Samueli School of Engineering and Applied Science, Mechanical and Aerospace Engineering Department, Biomedical Inter-Department Program, Los Angeles, CA 90095-1597, USA.
J Biophotonics. 2011 May;4(5):305-14. doi: 10.1002/jbio.201000069.
A previously developed inverse method was applied to in vivo normal-hemispherical spectral reflectance measurements taken on the inner and outer forearm as well as the forehead of healthy white Caucasian and black African subjects. The inverse method was used to determine the thickness and melanin concentration in the epidermis, dermal blood volume fraction and oxygen saturation, and skin's spectral scattering coefficient. It was established that changes in melanin concentration due to racial difference and tanning, and differences in epidermal thickness and blood volume with anatomical location were detectable. The retrieved values were also consistent with independent measurements reported in the literature. The same method could be used for optical diagnosis of pathologies affecting the structure and pigmentation of human skin.
先前开发的反演方法应用于活体正常半球光谱反射率测量，测量对象为健康的白种人和黑种人个体的前臂内外侧和前额。反演方法用于确定表皮的厚度和黑色素浓度、真皮的血液体积分数和氧饱和度以及皮肤的光谱散射系数。结果表明，由于种族差异和晒黑导致的黑色素浓度变化，以及表皮厚度和血液体积随解剖位置的差异是可检测的。所得到的数值也与文献中报道的独立测量值一致。该方法也可用于影响人类皮肤结构和色素沉着的病变的光学诊断。
