鼻息肉患者的一种新的氧化应激标志物：晚期氧化蛋白产物（AOPP）。
A new oxidative stress marker in patients with nasal polyposis: advanced oxidation protein products (AOPP).
作者信息
Veyseller B, Aksoy E, Ertaş B, Keskin M, Ozturan O, Yildirim Y S, Bayraktar E G I, Oztürk H
机构信息
Department of Otorhinolaryngology and Head and Neck Surgery, Istanbul, Turkey.
出版信息
B-ENT. 2010;6(2):105-9.
OBJECTIVES
The aim of this study was to determine whether levels of advanced oxidation protein products (AOPP) can be used a marker of oxidative stress in the etiology of nasal polyposis.
MATERIALS AND METHODS
Twenty-four patients diagnosed with nasal polyposis in Haseki Education and Research Hospital ENT Department between March and June 2008 were included in the study. The AOPP serum levels in NP patients and 24 healthy controls were measured with spectrophotometry and the results were compared statistically.
RESULTS
AOPP levels were significantly higher in the study group compared with the control group.
CONCLUSION
Our findings suggest that AOPP levels can be used as a marker of oxidative stress in patients with nasal polyposis. Future studies are neccessary to evaluate the efficacy of antioxidant therapy.
目的
本研究旨在确定晚期氧化蛋白产物（AOPP）水平是否可作为鼻息肉病因中氧化应激的标志物。
材料与方法
纳入2008年3月至6月在哈塞基教育与研究医院耳鼻喉科诊断为鼻息肉的24例患者。采用分光光度法测量鼻息肉患者和24名健康对照者的血清AOPP水平，并对结果进行统计学比较。
结果
研究组的AOPP水平显著高于对照组。
结论
我们的研究结果表明，AOPP水平可作为鼻息肉患者氧化应激的标志物。未来有必要开展研究评估抗氧化治疗的疗效。
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