National Center for Natural Products Research, School of Pharmacy, University of Mississippi, University, Mississippi 38677, USA.
J Agric Food Chem. 2010 Aug 25;58(16):8887-94. doi: 10.1021/jf101598g. Epub 2010 Aug 3.
A method was developed and validated for the analysis of 21 elements in various botanicals and dietary supplements using ICP-MS. Closed-vessel microwave digestion of botanicals and dietary products was assisted by various different procedures. The samples digested with concentrated nitric and hydrochloric acid (8:2) revealed the best recoveries (91-106%) using the reference certified materials (SRM 3280, SRM 1566b). The method was validated for linearity, precision, accuracy, LOD, and LOQ. The LOD was found to be in the range from 0.005 to 1.09 ng/mL with the exception of potassium. Eleven botanicals and 21 dietary supplements were analyzed. Among the analyzed elements, K was the most abundant followed by Na, Mg, Al, Ca, Mn, and Fe, whereas V, Cr, Co, Ni, Se, Cd, Hg, and Pb were present in low concentrations in most of the samples. The results showed that the ICP-MS method is a simple, fast, and reliable for the multielement determination in dietary supplements and botanicals.
建立并验证了一种使用 ICP-MS 分析各种植物药和膳食补充剂中 21 种元素的方法。采用不同的程序辅助植物药和膳食产品的密闭微波消解。使用参考标准物质（SRM 3280、SRM 1566b），用浓硝酸和盐酸（8:2）消解的样品显示出最佳的回收率（91-106%）。该方法针对线性、精密度、准确度、检出限和定量限进行了验证。检出限范围为 0.005-1.09ng/mL，除钾外。分析了 11 种植物药和 21 种膳食补充剂。在所分析的元素中，钾的含量最丰富，其次是钠、镁、铝、钙、锰和铁，而钒、铬、钴、镍、硒、镉、汞和铅在大多数样品中的含量较低。结果表明，ICP-MS 法是一种简单、快速、可靠的方法，可用于膳食补充剂和植物药中的多元素测定。
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