Department of Chemistry, The University of Vermont, 82 University Place, Burlington, Vermont 05405, USA.
Org Lett. 2010 Sep 3;12(17):3906-9. doi: 10.1021/ol101606v.
A one-pot multicomponent procedure for the synthesis of highly functionalized pyrrolidine rings through a domino 2-aza-Cope-[3 + 2] dipolar cycloaddition sequence has been demonstrated. This protocol was found to be both high-yielding and stereoselective for the endo cycloadduct.
通过多米诺 2-氮杂-Cope-[3 + 2]环加成序列,展示了一锅多组分方法合成高官能化吡咯烷环的方法。该方案被发现对于endo 环加成产物具有高产率和立体选择性。