Jones Amanda C, May Jeremy A, Sarpong Richmond, Stoltz Brian M
Angew Chem Int Ed Engl. 2014 Mar 3;53(10):2556-91. doi: 10.1002/anie.201302572.
Catalysis and synthesis are intimately linked in modern organic chemistry. The synthesis of complex molecules is an ever evolving area of science. In many regards, the inherent beauty associated with a synthetic sequence can be linked to a certain combination of the creativity with which a sequence is designed and the overall efficiency with which the ultimate process is performed. In synthesis, as in other endeavors, beauty is very much in the eyes of the beholder. It is with this in mind that we will attempt to review an area of synthesis that has fascinated us and that we find extraordinarily beautiful, namely the combination of catalysis and sigmatropic rearrangements in consecutive and cascade sequences.
在现代有机化学中，催化与合成紧密相连。复杂分子的合成是一个不断发展的科学领域。在许多方面，与一个合成序列相关的内在美可以与序列设计的创造力和最终过程执行的整体效率的某种组合联系起来。在合成中，如同在其他领域一样，美很大程度上取决于旁观者的眼光。正是出于这个考虑，我们将尝试回顾一个令我们着迷且我们认为极其美妙的合成领域，即催化与连续和串联序列中的σ迁移重排的结合。
