Duvauchelle C L, Ettenberg A
Department of Psychology, University of California, Santa Barbara 93106.
Pharmacol Biochem Behav. 1991 Mar;38(3):645-50. doi: 10.1016/0091-3057(91)90027-y.
A Conditioned Place Preference test procedure [Ettenberg and Duvauchelle (13)] was used to investigate the effects of dopamine antagonist challenge on the rewarding properties of medial prefrontal cortex (MPFC) electrical stimulation. Rats exhibited strong preferences for the side of a two-compartment test apparatus in which they experienced sessions of experimenter-administered 0.5-s trains of MPFC sine-wave 60-Hz stimulation. Pretreatment with the neuroleptic dopamine antagonist drug, haloperidol (0.0, 0.15, or 0.3 mg/kg IP), resulted in a dose-dependent reduction in the magnitude of observed place preferences. Preference tests were conducted 24 hours after drug-conditioning trials and, hence, were not subject to motoric or other nonspecific actions of the neuroleptic treatments. In a control experiment, haloperidol did not block the place aversions produced by dorsomedial tegmental stimulation. Animals can, therefore, recall place-associations formed in the presence of haloperidol, a result which challenges "state-dependent learning" explanations of the drug's actions. Together, these results are consistent with the view that dopamine neurotransmission is involved in the rewarding consequences of electrical stimulation in the medial prefrontal cortex.
采用条件性位置偏爱测试程序[埃滕伯格和迪瓦舍尔（13）]来研究多巴胺拮抗剂激发对内侧前额叶皮质（MPFC）电刺激奖赏特性的影响。大鼠对双隔室测试装置的一侧表现出强烈偏爱，在该侧它们经历了实验者给予的0.5秒时长的MPFC 60赫兹正弦波刺激。用抗精神病多巴胺拮抗剂药物氟哌啶醇（0.0、0.15或0.3毫克/千克腹腔注射）进行预处理，导致观察到的位置偏爱程度呈剂量依赖性降低。偏爱测试在药物条件试验24小时后进行，因此不受抗精神病药物治疗的运动或其他非特异性作用影响。在一项对照实验中，氟哌啶醇并未阻断背内侧被盖区刺激产生的位置厌恶。因此，动物能够回忆在氟哌啶醇存在时形成的位置关联，这一结果对该药物作用的“状态依赖性学习”解释提出了挑战。总之，这些结果与多巴胺神经传递参与内侧前额叶皮质电刺激奖赏后果这一观点一致。
