Robertson A, Laferrière A
Department of Psychology, University of Alberta, Edmonton, Canada.
Behav Neurosci. 1989 Aug;103(4):770-8. doi: 10.1037//0735-7044.103.4.770.
This study involved 2 tests of conditioned reward with self-stimulation (SS) of the prefrontal cortex. In Experiment 1, rats were tested for a conditioned taste preference (CTP) induced by pairing a novel flavor with SS of the medial prefrontal cortex (MC). Normal rats displayed a CTP. Rats with bilateral cuts of the connections between the MC and sulcal prefrontal cortex (SC) did not show a CTP. In Experiment 2, similar cuts had no effect on the ability of SC SS to promote a CTP, showing that the cuts spare the ability to learn a CTP. In Experiment 3, rats were tested for a conditioned place preference by pairing MC SS with environmental cues. Lesioned rats, but not intact rats, had a CPP. Results suggest the presence of prepotent relations, dependent on intrinsic prefrontal connections, between the rewarding effects of prefrontal stimulation and distinct sensorimotor domains.
本研究涉及两项前额叶皮质自我刺激（SS）的条件性奖赏测试。在实验1中，对大鼠进行条件性味觉偏好（CTP）测试，方法是将一种新口味与内侧前额叶皮质（MC）的SS配对。正常大鼠表现出CTP。内侧前额叶皮质（MC）与沟回前额叶皮质（SC）之间连接被双侧切断的大鼠未表现出CTP。在实验2中，类似的切断对沟回前额叶皮质（SC）的SS促进CTP的能力没有影响，表明这种切断未损害学习CTP的能力。在实验3中，通过将内侧前额叶皮质（MC）的SS与环境线索配对，对大鼠进行条件性位置偏好测试。受损大鼠而非完整大鼠有条件性位置偏好（CPP）。结果表明，前额叶刺激的奖赏效应与不同的感觉运动域之间存在依赖于前额叶内在连接的优势关系。
