一项关于联合腮腺炎、麻疹、风疹疫苗的随机单盲试验，以评估英国人群的血清学反应和不良反应。

A randomised single blind trial of a combined mumps measles rubella vaccine to evaluate serological response and reactions in the UK population.

作者信息

Edees S, Pullan C R, Hull D

机构信息

Department of Child Health, University Hospital, Queen's Medical Centre, Nottingham.

出版信息

Public Health. 1991 Mar;105(2):91-7. doi: 10.1016/s0033-3506(05)80282-3.

DOI:10.1016/s0033-3506(05)80282-3

PMID:2068243

Abstract

Four hundred and twenty children were randomly assigned to receive either mumps measles rubella (MMR) vaccine (207) or measles vaccine (213) in a single blind study, to investigate the reactogenicity and serology of the MMR vaccine. There was no significant difference between the number of children developing symptoms after MMR vaccination to those developing symptoms after measles vaccination. Both vaccines are associated with a rash, temperature and restlessness five to thirteen days after vaccination. The serological response to measles vaccine was similar in both groups with 92-6% seroconverting with MMR, and 96-8% with measles. Seroconvertion against mumps and rubella with the MMR vaccine was 88% and 96% respectively. This study confirms the safety and efficacy of the MMR vaccine in a UK population.

摘要

在一项单盲研究中，420名儿童被随机分配接受腮腺炎麻疹风疹（MMR）疫苗（207名）或麻疹疫苗（213名），以调查MMR疫苗的反应原性和血清学情况。接种MMR疫苗后出现症状的儿童数量与接种麻疹疫苗后出现症状的儿童数量之间没有显著差异。两种疫苗都与接种后五至十三天出现皮疹、发热和烦躁不安有关。两组对麻疹疫苗的血清学反应相似，MMR疫苗的血清转化率为92.6%，麻疹疫苗为96.8%。MMR疫苗对腮腺炎和风疹的血清转化率分别为88%和96%。这项研究证实了MMR疫苗在英国人群中的安全性和有效性。