麻疹、腮腺炎和风疹疫苗的血清学评估
Serological evaluation of a measles, mumps, and rubella vaccine.
作者信息
Robertson C M, Bennett V J, Jefferson N, Mayon-White R T
机构信息
Department of Community Medicine, Oxfordshire Health Authority, Headington.
出版信息
Arch Dis Child. 1988 Jun;63(6):612-6. doi: 10.1136/adc.63.6.612.
Combined measles, mumps, and rubella vaccination is soon to become available in Britain in the routine immunisation programme. A controlled study was performed in 319 children, aged 13 months, to assess the antibody response and clinical reactions to a new combined measles, mumps, and rubella vaccine in comparison with a single component measles vaccine. In the children who received the combined vaccine, seroconversion was established in 93% for measles, 99% for rubella, and 100% for mumps. In the children who received the single measles vaccine, seroconversion was established in 92% for measles and in none for rubella and mumps. There was no increase in clinical reactions after the measles, mumps, and rubella vaccine compared with the measles vaccine. These results suggest that this combined vaccine would be effective and safe in a British population and give further support for the introduction of the combined measles, mumps, and rubella vaccine to Britain.
麻疹、腮腺炎和风疹联合疫苗即将在英国纳入常规免疫计划。对319名13个月大的儿童进行了一项对照研究，以评估一种新的麻疹、腮腺炎和风疹联合疫苗与单组分麻疹疫苗相比的抗体反应和临床反应。在接种联合疫苗的儿童中，麻疹血清转化率为93%，风疹为99%，腮腺炎为100%。在接种单组分麻疹疫苗的儿童中，麻疹血清转化率为92%，风疹和腮腺炎均无血清转化。与麻疹疫苗相比，接种麻疹、腮腺炎和风疹联合疫苗后临床反应没有增加。这些结果表明，这种联合疫苗在英国人群中有效且安全，并为在英国引入麻疹、腮腺炎和风疹联合疫苗提供了进一步支持。
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