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2007 年坦桑尼亚人间裂谷热暴发的流行病学和临床方面。

Epidemiologic and clinical aspects of a Rift Valley fever outbreak in humans in Tanzania, 2007.

机构信息

Tanzania Ministry of Health and Social Welfare, Dar es Salaam, Tanzania.

出版信息

Am J Trop Med Hyg. 2010 Aug;83(2 Suppl):22-7. doi: 10.4269/ajtmh.2010.09-0318.

DOI:10.4269/ajtmh.2010.09-0318
PMID:20682902
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2913502/
Abstract

In January 2007, an outbreak of Rift Valley fever (RVF) was detected among humans in northern Tanzania districts. By the end of the outbreak in June, 2007, 511 suspect RVF cases had been recorded from 10 of the 21 regions of Tanzania, with laboratory confirmation of 186 cases and another 123 probable cases. All confirmed RVF cases were located in the north-central and southern regions of the country, with an eventual fatality rate of 28.2% (N = 144). All suspected cases had fever; 89% had encephalopathy, 10% hemorrhage, and 3% retinopathy. A total of 169 (55%) of the 309 confirmed or probable cases were also positive for malaria as detected by peripheral blood smear. In a cohort of 20 RVF cases with known outcome that were also positive for human immunodeficiency virus, 15 (75%) died. Contact with sick animals and animal products, including blood, meat, and milk, were identified as major risk factors of acquiring RVF.

摘要

2007 年 1 月,坦桑尼亚北部地区发现人间裂谷热(RVF)爆发。到 2007 年 6 月疫情结束时,坦桑尼亚 21 个地区中的 10 个地区记录了 511 例疑似 RVF 病例,实验室确诊 186 例,另有 123 例可能病例。所有确诊的 RVF 病例均位于该国中北部和南部地区,最终病死率为 28.2%(N=144)。所有疑似病例均有发热;89%有脑病,10%有出血,3%有视网膜病变。在 309 例确诊或可能的病例中,共有 169 例(55%)通过外周血涂片也被检出疟疾阳性。在已知结局的 20 例 RVF 病例队列中,也有 15 例(75%)死亡。与病畜及其产品接触,包括血液、肉类和牛奶,被确定为感染 RVF 的主要危险因素。

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