2006-2007 年东非裂谷热暴发期间疑似动物和人间病例的病理学研究。
Pathologic studies on suspect animal and human cases of Rift Valley fever from an outbreak in Eastern Africa, 2006-2007.
机构信息
Infectious Disease Pathology Branch, Division of Viral and Rickettsial Diseases, National Center for Zoonotic, Vector-Borne, and Enteric Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA.
出版信息
Am J Trop Med Hyg. 2010 Aug;83(2 Suppl):38-42. doi: 10.4269/ajtmh.2010.09-0463.
Rift Valley fever (RVF) is an important viral zoonotic disease in Africa with periodic outbreaks associated with severe disease, death, and economic hardship. During the 2006-2007 outbreaks in Eastern Africa, postmortem and necropsy tissue samples from 14 animals and 20 humans clinically suspected of RVF were studied with histopathologic evaluation and immunohistochemical (IHC) assays. Six animal and 11 human samples had IHC evidence of Rift Valley fever virus (RVFV) antigens. We found that extensive hepatocellular necrosis without prominent inflammatory cell infiltrates is the most distinctive histopathologic change in liver tissues infected with RVFV. Pathologic studies on postmortem tissue samples can help establish the diagnosis of RVF, differentiating from endemic diseases with clinical manifestations similar to RVF, such as malaria, leptospirosis, or yellow fever.
裂谷热（RVF）是一种重要的病毒性人畜共患病，在非洲周期性爆发，与严重疾病、死亡和经济困难有关。在 2006-2007 年东非的爆发期间，对 14 只动物和 20 名临床疑似裂谷热的人类的死后和尸检组织样本进行了组织病理学评估和免疫组织化学（IHC）检测。6 只动物和 11 名人类样本的 IHC 检测有裂谷热病毒（RVFV）抗原的证据。我们发现，广泛的肝细胞坏死而没有明显的炎症细胞浸润是感染 RVFV 的肝脏组织中最具特征性的组织病理学改变。对死后组织样本的病理学研究有助于建立 RVF 的诊断，将其与临床表现与 RVF 相似的地方性疾病区分开来，如疟疾、钩端螺旋体病或黄热病。
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