Gastrointestinal and Liver Pathology Research Laboratory, Department of Pathology, Karolinska Institute and University Hospital, 17176, Stockholm, Sweden.
Anticancer Res. 2010 Jul;30(7):3019-22.
Colon carcinomas arising in gut-associated lymphoid tissue (GALTC) are termed dome carcinomas (DC) because of their protruding phenotype. Only 8 GALTC cases have been reported in the literature.
A female patient, aged 53, having a familial pedigree of colon cancer, uterine cervix cancer and brain tumour developed a signet-ring carcinoma in the cecum and 10 years later endometrial cancer. While asymptomatic, a plaque-like protrusion in the colon was detected at surveillance colonoscopy. Histology demonstrated a protruding GALTC. The surgical specimen showed four additional carcinomas: 2 GALTC (non-protruding) and 2 carcinomas in lymphoid-free colonic mucosa (LFCMC).
Since adenomas could not be demonstrated neither previously nor in the colectomy specimen, it is suggested that the GALTCs in this patient may have followed the GALT-carcinoma pathway.
起源于肠相关淋巴组织（GALTC）的结肠癌被称为穹窿状癌（DC），因为其外生性表现。文献中仅报道了 8 例 GALTC 病例。
一名 53 岁女性，有结肠癌、宫颈癌和脑瘤家族史，在盲肠发生了印戒细胞癌，10 年后又发生了子宫内膜癌。在无症状时，在结肠镜监测中发现结肠有斑块样隆起。组织学显示为外生性 GALTC。手术标本显示还有另外 4 个癌：2 个 GALTC（非外生性）和 2 个在无淋巴的结肠黏膜（LFCMC）中的癌。
由于之前和结肠切除术标本中均未发现腺瘤，因此推测该患者的 GALTC 可能遵循 GALT-癌途径。
