McCarthy Aoife J, Chetty Runjan
Department of Anatomical Pathology, Laboratory Medicine Program, University Health Network, Toronto ON, Canada.
World J Gastrointest Oncol. 2019 Jan 15;11(1):59-70. doi: 10.4251/wjgo.v11.i1.59.
To present a comprehensive review of the etiology, clinical features, macroscopic and pathological findings, and clinical significance of Gut-associated lymphoid tissue or "dome" carcinoma of the colon.
The English language medical literature on gut- or gastrointestinal-associated lymphoid tissue (GALT) or "dome" carcinoma of the colon was searched and appraised.
GALT/dome-type carcinomas of the colon are thought to arise from the M-cells of the lymphoglandular complex of the intestine. They are typically asymptomatic and have a characteristic endoscopic plaque- or "dome"-like appearance. Although the histology of GALT/dome-type carcinomas displays some variability, they are characterized by submucosal localization, a prominent lymphoid infiltrate with germinal center formation, tumor-infiltrating lymphocytes, absence of desmoplasia, and dilated glands lined by columnar epithelial cells with bland nuclear features and cytoplasmic eosinophilia. None of the patients reported in the literature with follow-up have developed metastatic disease or local recurrence.
Increased awareness amongst histopathologists of this variant of colorectal adenocarcinoma is likely to lead to the recognition of more cases.
全面综述结肠肠道相关淋巴组织或“穹顶”状癌的病因、临床特征、大体及病理表现以及临床意义。
检索并评估英文医学文献中关于结肠肠道或胃肠道相关淋巴组织（GALT）或“穹顶”状癌的内容。
结肠GALT/穹顶型癌被认为起源于肠道淋巴腺复合体的M细胞。它们通常无症状，具有特征性的内镜下斑块状或“穹顶”状外观。尽管GALT/穹顶型癌的组织学表现存在一定差异，但其特征为黏膜下定位、伴有生发中心形成的显著淋巴样浸润、肿瘤浸润淋巴细胞、无促纤维增生、以及由具有温和核特征和胞质嗜酸性的柱状上皮细胞衬覆的扩张腺体。文献报道的所有接受随访的患者均未发生转移性疾病或局部复发。
组织病理学家对这种结直肠腺癌变体的认识提高可能会使更多病例得到识别。
