Department of Master Course in Dentistry, Veiga de Almeida University, Rio de Janeiro, Brazil.
Implant Dent. 2010 Aug;19(4):314-22. doi: 10.1097/ID.0b013e3181dec322.
The aim of this study was to evaluate, clinically and histologically, the tissues formed in human alveolar sockets filled with bovine morphogenetic protein/bovine organic matrix (BOM) and absorbable membrane (AM) immediately after extraction.
Forty-six human alveolar sockets, exhibiting buccal bone defects were selected for this study. Group 1 received no biomaterial to serve as control. Sockets from group 2 were filled with bovine bone morphogenetic protein (bBMP) associated with bOM. The association of bBMP/bOM/AM filled the alveolar defects from group 3. AM was placed over the defects from group 4. Clinical evaluation analyzed ridge width before biomaterial filling and 4 months after filling. Fifteen specimens were collected from groups 2, 3, and 4 for histologic analyses.
Clinical results showed no significant augmentation on the control group (-0.16 +/- 0.28 mm). All test sites, groups 2, 3, and 4, showed relevant ridge width augmentation (3.0 +/- 0.5 mm, 2.4 +/- 0.3 mm, and 2.9 +/- 0.6 mm, respectively) and no resorption. Histologically, all experimental alveolar sockets showed active bone formation with osteoid, osteoblasts, and cell differentiation.
On the basis of this study, we concluded that bBMP/bOM with or without AM could preserve the ridge showing viable bone formation for future implant placement.
本研究旨在评估即刻拔牙后用牛骨形成蛋白/牛有机基质（BOM）和可吸收膜（AM）填充的人牙槽窝内形成的组织，从临床和组织学方面进行评价。
本研究选择 46 个人牙槽窝，这些牙槽窝颊侧骨有缺损。第 1 组不使用任何生物材料作为对照。第 2 组牙槽窝填充牛骨形成蛋白（bBMP）和 bOM。第 3 组牙槽窝填充 bBMP/bOM/AM 以填充牙槽骨缺损。第 4 组牙槽窝用 AM 覆盖。临床评估分析了生物材料填充前和填充后 4 个月牙槽嵴的宽度。从第 2、3 和 4 组收集了 15 个标本进行组织学分析。
临床结果显示，对照组（-0.16 +/- 0.28 mm）无明显增加。所有测试部位，即第 2、3 和 4 组，均显示出相关的牙槽嵴宽度增加（分别为 3.0 +/- 0.5 mm、2.4 +/- 0.3 mm 和 2.9 +/- 0.6 mm），且无吸收。组织学上，所有实验性牙槽窝均显示出活跃的骨形成，有类骨质、成骨细胞和细胞分化。
基于本研究，我们得出结论，bBMP/bOM 联合或不联合 AM 可保持牙槽嵴，为未来种植体的植入提供有活力的骨形成。
