Al-Sabbagh Mohanad, Burt John, Barakat Ahmed, Kutkut Ahmad, El-Ghannam Ahmed
USA.
J Int Acad Periodontol. 2013 Jul;15(3):91-8.
The purpose of this study was to histologically evaluate newly generated vital bone using porous granules of bioactive and resorbable silica-calcium phosphate nanocomposite (SCPC) in extraction sockets.
Six patients with a non-restorable maxillary central incisor requiring extraction followed by implant placement participated in the study. Extraction sockets were grafted with granules of SCPC. After 6 months, a bone core sample was retrieved from the center of the healed socket for histologic analysis, and dental implants were placed. Alveolar bone width was clinically assessed immediately after tooth extraction and 6 months after bone grafting, at the time of implant placement. Alveolar bone height was radiographically assessed immediately after tooth extraction and 6 months after extraction.
Histomorphometric analyses of sockets grafted with SCPC for 6 months revealed 46.8% +/- 14% new vital bone and 2.5% +/- 1.5% graft material remnants. In these sockets, the mean bone height resorption over the 6-month period of healing was 1.6 mm +/- 1.5 mm. The mean bone width resorption of 2 mm +/- 0.7 mm was found at the bone crest.
The results of this study suggest that SCPC graft material reduces the amount of change in alveolar ridge dimensions after tooth extraction and facilitates the regeneration of new vital bone.
本研究旨在通过组织学方法评估在拔牙窝中使用生物活性可吸收二氧化硅-磷酸钙纳米复合材料（SCPC）多孔颗粒新生成的活性骨。
6例需要拔除上颌中切牙并随后植入种植体的患者参与了本研究。拔牙窝用SCPC颗粒进行植骨。6个月后，从愈合牙槽窝中心获取骨芯样本进行组织学分析，并植入牙种植体。在拔牙后即刻以及植骨后6个月（即植入种植体时）对牙槽骨宽度进行临床评估。在拔牙后即刻以及拔牙后6个月对牙槽骨高度进行影像学评估。
对用SCPC植骨6个月的牙槽窝进行组织形态计量学分析显示，有46.8%±14%的新活性骨和2.5%±1.5%的移植材料残余。在这些牙槽窝中，愈合6个月期间的平均骨高度吸收为1.6 mm±1.5 mm。在牙槽嵴处发现平均骨宽度吸收为2 mm±0.7 mm。
本研究结果表明，SCPC移植材料可减少拔牙后牙槽嵴尺寸的变化量，并促进新活性骨的再生。
