Department of Ophthalmology, New Jersey Medical School, Newark, New Jersey, USA.
Ophthalmic Plast Reconstr Surg. 2010 Nov-Dec;26(6):438-42. doi: 10.1097/IOP.0b013e3181d18a64.
To describe 4 patients with histopathologically confirmed tarsal conjunctival nevi and to review the literature regarding nevi in this location.
Clinicopathologic series of 4 cases diagnosed at the New York Eye and Ear Infirmary between January 1990 and April 2009. PubMed was searched for reported cases of tarsal conjunctival nevi.
Four patients (mean age 44 years, median 50 years, range 5-70 years) with tarsal conjunctival nevi were identified (3.4% of all histopathologically diagnosed conjunctival nevi). These lesions presented in adulthood (3 cases) and were associated with elevation/nodularity (3 cases), gray-brown coloration (3 cases), physician-documented growth (1 case), madarosis (1 case), and intrinsic vessels (1 case). Histopathology revealed combined nevi centered in the posterior lamella of the eyelid, predominantly in peri-Meibomian gland distribution. Review of the literature identified 10 previously reported cases of tarsal nevi with detailed clinicopathologic correlation in 3 of these patients.
Tarsal conjunctival nevi are rare. Adult presentation; subjective and objective evidence of growth; and associated inflammation, vascularity, and eyelid margin changes may make clinical distinction of tarsal nevi from melanoma challenging. Biopsy, therefore, is prudent as histopathology alone allows documentation of the benign nature of these lesions.
描述 4 例经组织病理学证实的睑结膜痣患者，并复习该部位痣的相关文献。
回顾性分析 1990 年 1 月至 2009 年 4 月期间在纽约眼耳医院诊断的 4 例临床病理病例。通过 PubMed 检索报道的睑结膜痣病例。
共发现 4 例（平均年龄 44 岁，中位数 50 岁，范围 5-70 岁）睑结膜痣患者（所有组织病理学诊断为结膜痣的 3.4%）。这些病变发生于成年期（3 例），并伴有隆起/小结节（3 例）、灰棕色变色（3 例）、医生记录的生长（1 例）、睫毛缺失（1 例）和固有血管（1 例）。组织病理学显示，这些病变位于睑板后层，以睑板腺周围分布为主，痣细胞混合存在。复习文献，共发现 10 例先前报道的睑痣病例，其中 3 例有详细的临床病理相关性。
睑结膜痣罕见。成人发病；主观和客观的生长证据；以及相关的炎症、血管性和睑缘改变，可能使睑结膜痣与黑色素瘤的临床鉴别具有挑战性。因此，活检是明智的，因为仅凭组织病理学检查就能证明这些病变为良性。
