Department of Experimental Oncology, Mediterranean Institute of Oncology, Viagrande, CT, Italy.
Diagn Pathol. 2013 Apr 22;8:64. doi: 10.1186/1746-1596-8-64.
Melanocytic nevi are the most common tumors of the conjunctiva, accounting for 28% of all neoplastic lesions. These tumors, despite their benign behavior, share some atypical histological features with nevi found in other anatomic sites like the genital and acral regions, globally designated as nevi with site-related atypia. Moreover, in children and adolescents, rapidly growing conjunctival nevi show sometimes worrisome histological patterns in association with a prominent inflammatory infiltrate that may lead to diagnostic problems. In this paper we describe a juvenile compound nevus characterized by marked melanocytic atypia and severe inflammation, which can be considered a rare case of juvenile conjunctival atypical nevus. The final diagnosis relied on morphological and immunohistochemical characterization of the large epithelioid melanocytic cells, and on the results of FISH analysis.
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黑素细胞痣是结膜最常见的肿瘤，占所有肿瘤病变的 28%。这些肿瘤尽管具有良性行为，但与生殖器和肢端等其他解剖部位发现的痣具有一些不典型的组织学特征，全球统称为与部位相关的不典型痣。此外，在儿童和青少年中，快速生长的结膜痣有时会出现令人担忧的组织学模式，伴有明显的炎症浸润，这可能导致诊断问题。在本文中，我们描述了一个具有明显黑色素细胞不典型性和严重炎症的青少年复合痣，可以认为是一种罕见的青少年结膜不典型痣。最终诊断依赖于大上皮样黑色素细胞的形态学和免疫组织化学特征，以及 FISH 分析的结果。
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