Department of Pharmacology, Weill Cornell Medical College, Cornell University, New York, USA.
Pflugers Arch. 2010 Nov;460(6):953-64. doi: 10.1007/s00424-010-0865-6. Epub 2010 Aug 4.
In biological systems, carbon dioxide exists in equilibrium with bicarbonate and protons. The individual components of this equilibrium (i.e., CO₂, HCO₃⁻, and H(+)), which must be sensed to be able to maintain cellular and organismal pH, also function as signals to modulate multiple physiological functions. Yet, the molecular sensors for CO₂/HCO₃⁻/pH remained unknown until recently. Here, we review recent progress in delineating molecular and cellular mechanisms for sensing CO₂, HCO₃⁻, and pH.
在生物系统中,二氧化碳与碳酸氢根和质子处于平衡状态。为了维持细胞和机体的 pH 值,必须感知这种平衡的各个组成部分(即 CO₂、HCO₃⁻和 H(+)),它们也作为信号来调节多种生理功能。然而,直到最近,CO₂/HCO₃⁻/pH 的分子传感器仍然未知。在这里,我们回顾了最近在阐明 CO₂、HCO₃⁻和 pH 感测的分子和细胞机制方面的进展。