Department of Orthopedics Surgery, The Second Hospital of Medical College, Zhejiang University, Hangzhou, PR China.
Phytother Res. 2011 Mar;25(3):351-6. doi: 10.1002/ptr.3267.
Diallyl sulphide (DAS) is known for its antioxidant, anticancer and detoxifying properties. The aim of this study was to investigate the effect of DAS on rabbit articular chondrocytes and cartilage in experimental osteoarthritis (OA) induced by anterior cruciate ligament transection (ACLT). DAS inhibited matrix metalloproteinase-1 (MMP-1), MMP-3 and MMP-13 expression in interleukin-1beta (IL-1β)-induced chondrocytes. In an in vivo study, DAS ameliorated cartilage degradation as assessed by morphological and histological examination. Messenger RNA expression of MMP-1, MMP-3, MMP-13 and IL-1β was inhibited by DAS in cartilage. In addition, DAS increased the collagen II level in cartilage. The results suggest that DAS may protect cartilage in the development of OA.
二烯丙基二硫（DAS）具有抗氧化、抗癌和解毒作用。本研究旨在探讨 DAS 对前交叉韧带切断（ACLT）诱导的实验性骨关节炎（OA）兔关节软骨细胞和软骨的影响。DAS 抑制白细胞介素-1β（IL-1β）诱导的软骨细胞中基质金属蛋白酶-1（MMP-1）、MMP-3 和 MMP-13 的表达。在体内研究中，DAS 通过形态学和组织学检查改善了软骨降解。DAS 抑制软骨中 MMP-1、MMP-3、MMP-13 和 IL-1β 的信使 RNA 表达。此外，DAS 增加了软骨中胶原 II 的水平。结果表明，DAS 可能在 OA 的发展过程中保护软骨。
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