Institute of Living Systems, Immanuel Kant Baltic Federal University, A. Nevskogo Street 14, 236016 Kaliningrad, Russia.
Department of Bionanotechnology, Kemerovo State University, Krasnaya Street 6, 650043 Kemerovo, Russia.
Molecules. 2021 Apr 20;26(8):2391. doi: 10.3390/molecules26082391.
Osteoarthritis (OA) is a degenerative joint disease and an important cause of incapacitation. There is a lack of drugs and effective treatments that stop or slow the OA progression. Modern pharmacological treatments, such as analgesics, have analgesic effects but do not affect the course of OA. Long-term use of these drugs can lead to serious side effects. Given the OA nature, it is likely that lifelong treatment will be required to stop or slow its progression. Therefore, there is an urgent need for disease-modifying OA treatments that are also safe for clinical use over long periods. Phytonutraceuticals are herbal products that provide a therapeutic effect, including disease prevention, which not only have favorable safety characteristics but may have an alleviating effect on the OA and its symptoms. An estimated 47% of OA patients use alternative drugs, including phytonutraceuticals. The review studies the efficacy and action mechanism of widely used phytonutraceuticals, analyzes the available experimental and clinical data on the effect of some phytonutraceuticals (phytoflavonoids, polyphenols, and bioflavonoids) on OA, and examines the known molecular effect and the possibility of their use for chondroprotection.
骨关节炎（OA）是一种退行性关节疾病，也是导致失能的重要原因。目前缺乏能够阻止或减缓 OA 进展的药物和有效治疗方法。现代药理学治疗方法，如镇痛药，具有镇痛作用，但不会影响 OA 的病程。这些药物长期使用可能会导致严重的副作用。鉴于 OA 的性质，很可能需要终身治疗才能阻止或减缓其进展。因此，迫切需要安全有效的治疗 OA 的药物，这些药物也可以长期安全使用。植物营养药物是提供治疗效果的草药产品，包括疾病预防，它们不仅具有良好的安全性特征，而且可能对 OA 及其症状有缓解作用。据估计，47%的 OA 患者使用替代药物，包括植物营养药物。本综述研究了广泛使用的植物营养药物的疗效和作用机制，分析了一些植物营养药物（植物类黄酮、多酚和生物类黄酮）对 OA 影响的现有实验和临床数据，并研究了已知的分子作用及其用于软骨保护的可能性。
