Sato T, Kunishi K, Kameyama A, Takano T, Saito D
Department of Internal Medicine, Ibara City Hospital.
Kokyu To Junkan. 1991 Apr;39(4):349-53.
Effects of nifedipine, a Ca(++)-channel blocker, on smoking-induced hemodynamic changes were studied in 35 habitual male smokers. They were divided into three groups: 20 healthy persons (G1), 11 patients with essential hypertension (G2) who were under nifedipine treatment, and 4 patients (G3) with essential hypertension but who were receiving no medication. After abstaining from smoking for more than 12 hours, they smoked, within 10 minutes, two filtered cigarettes each containing 2 mg of nicotine. Hemodynamic parameters were measured and blood samples were taken before and 5, 10, and 30 minutes after beginning to smoke. In each group, smoking produced significant increases in blood pressure, heart rate and cardiac output. Plasma adrenaline increased significantly in 3 groups, and tended to be highest in G2. Plasma noradrenaline was the highest in G2 predominantly, but did not change after smoking. These results indicate that a smoking-induced hyperdynamic state including vasoconstriction due to catecholamine release might not depend on the calcium channel which is blocked by nifedipine, and the reflex activation of the sympathetic nerve system would develop in the presence of nifedipine.
在35名男性习惯性吸烟者中研究了钙通道阻滞剂硝苯地平对吸烟引起的血流动力学变化的影响。他们被分为三组：20名健康人（G1组）、11名正在接受硝苯地平治疗的原发性高血压患者（G2组）以及4名未接受任何药物治疗的原发性高血压患者（G3组）。在戒烟超过12小时后，他们在10分钟内每人吸了两支每支含2毫克尼古丁的过滤嘴香烟。在开始吸烟前以及吸烟开始后5、10和30分钟测量血流动力学参数并采集血样。在每组中，吸烟均使血压、心率和心输出量显著增加。三组血浆肾上腺素均显著升高，且在G2组中往往最高。血浆去甲肾上腺素主要在G2组中最高，但吸烟后未发生变化。这些结果表明，吸烟引起的包括因儿茶酚胺释放导致血管收缩的高动力状态可能不依赖于被硝苯地平阻断的钙通道，并且在硝苯地平存在的情况下交感神经系统会发生反射性激活。
